Introduction: The Evolution of CJC-1295
CJC-1295 was originally developed by the Canadian biotech company ConjuChem as a next-generation GHRH (Growth Hormone-Releasing Hormone) analog. Its purpose was clear: to overcome the short biological half-life of natural GHRH and enhance its clinical and research viability.
This led to the emergence of two distinct versions:
- CJC-1295 with DAC: A long-acting analog modified with a Drug Affinity Complex (DAC) that binds to albumin for prolonged circulation.
- CJC-1295 without DAC (NO DAC): A shorter-acting version without the DAC modification, mimicking the natural pulsatile rhythm of endogenous GHRH.
Today, both versions are widely used in research involving growth hormone regulation, metabolic studies, circadian rhythm modeling, and tissue repair.
Side-by-Side Comparison
Feature | CJC-1295 with DAC | CJC-1295 without DAC (NO DAC) |
---|---|---|
Type | Long-acting GHRH analog | Short-acting GHRH analog |
Half-life | 6–8 days | ~30 minutes |
GH Release | Sustained, non-pulsatile | Sharp, pulsatile |
Injection Frequency | 1–2 times per week | 1–2 times daily |
Common Stack | Solo or with GHRP/Ipamorelin | Strongly recommended with GHRP/Ipamorelin |
Research Focus | Chronic GH elevation, anti-aging, fat metabolism | Circadian GH modeling, recovery, cognitive studies |
Mechanism of Action: Deep Dive
CJC-1295 with DAC is structured to bind with serum albumin, allowing it to stay in the bloodstream for days and stimulate GH release consistently. This mimics long-term GH elevation and is favored in studies involving:
- Fat loss
- Muscle preservation
- IGF-1 regulation
- Anti-aging
However, prolonged elevation of GH may potentially downregulate natural feedback loops, so it is used carefully in long-term models.
CJC-1295 NO DAC behaves more like native GHRH, being rapidly cleared after triggering a distinct pulse of GH. This version is ideal for:
- Modeling natural GH rhythms
- Sleep and recovery studies
- Daily GH stimulation patterns
It is commonly stacked with Ipamorelin to generate synergistic GH pulses that better simulate physiologic release.
Suggested Research Dosages
Compound | Suggested Dose | Notes |
---|---|---|
CJC-1295 DAC | 1–2 mg, 1–2x weekly | Can be used solo or with GHRP |
CJC-1295 NO DAC | 100–200 mcg, 1–2x daily | Should be used with Ipamorelin |
Recommended Combo | CJC-1295 NO DAC 100 mcg + Ipamorelin 100 mcg | Once daily (evening) to mimic natural GH peak |
For laboratory research use only. Not for human or veterinary application.
Research Usage Guidelines
- For laboratory research only
Not for diagnostic, therapeutic, or human use. Ensure compliance with your jurisdiction’s regulations. - Control dosage frequency
- Overuse of DAC may elevate GH levels too long.
- NO DAC requires consistent timing and routine due to its short half-life.
- Do not confuse DAC and NO DAC dosing
They differ drastically in potency and duration. - Storage & Reconstitution
- Store lyophilized powder at -20°C.
- Reconstitute with bacteriostatic water.
- Once mixed, store at 2–8°C and use within 5–7 days.
- Avoid shaking or repeated freeze-thaw cycles.
- Use stacking cautiously
Synergistic GH pulses from combinations like NO DAC + Ipamorelin are potent and should be timed carefully in research models. - Document each experiment precisely
Track dosage, frequency, time, and observed responses to optimize reproducibility.
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